| Title: Trifunctional probe for target identification
Contact: Mary O'Reilly
Description: This illustration is on the cover of the September, 2009 issue of the journal Chemistry & Biology to illustrate the article by Xu, et al. “Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing” Chem. Biol. 2009, 16, 980-9.
To identify HDAC3 as the inhibitor’s target, a trifunctional chemical probe was used that incorporated the inhibitor, a handle for cross-linking, and a handle for detection.
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| Title: Human Heart
Contact: Science Picture Company
Description: A close-up view of the human heart.
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| Title: Human musculature front and back
Contact: Carlyn Iverson
Description: Anatomical illustration, human musculature, front musclulature, back musculature
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| Title: The Exploding Cell
Contact: Elizabeth Morales
Description: A fanciful illustration of the components of the eukaryotic animal cell
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| Title: The Pancreas and Digestive System
Contact: Jane Whitney
Description: Labeled diagram of the pancreas and pancreatic duct and its orientation to other organs inside the body, for a grade 6 textbook.
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| Title: Dumbbell rowing anatomy
Contact: William Hamilton
Description: Female athlete demonstrating dumbbell rowing exercise.
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| Title: Memory Loss
Contact: Travis Vermilye
Description: Editorial Illustration on memory loss and Alzheimer's disease.
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| Title: Supine breast examination
Contact: Pam Little, CMI
Description: Patient placement for supine breast examination
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| Title: anatomy & physiology self portrait
Contact: Steven Melendrez
Description: Facial anatomy showing selective features.
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| Title: HDAC7 inhibitor restores function to CFTR
Contact: Mary O'Reilly
Description: The cystic fibrosis transmembrane conductance regulator is a cell surface chloride channel that works to maintain proper hydration of airway epithelium. Mutation of this channel is implicated in cystic fibrosis, but a small molecule histone deacetylase inhibitor is able to restore function to the mutated channel. Hutt, et al. “Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.” Nature Chem.Biol. 2010, 6, 25-33.
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| Title: Human Gender Comparison
Contact: Diana Marques
Description: Comparison of male (left) and female human skulls from a frontal and side views. Commissioned by the Smithsonian Institution to use on the website of an exhibition of the Natural History Museum
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| Title: Ear
Contact: Jane Whitney
Description: For a grade 8 student text. Shows the balance of air pressure on either side of the ear drum.
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| Title: Sciatica
Contact: William Hamilton
Description: Human vertebral section demonstrating a ruptured disc and pressure on nerve.
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| Title: Sagittal Female Pelvis
Contact: Travis Vermilye
Description: Sagittal Female Pelvis. Carbon Dust
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| Title: Posterior Fixation Lumbar Spine
Contact: Pam Little, CMI
Description: Use of fixation devices to stabilize lumbar spine
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| Title: Forensic Sculpture
Contact: Chris Sanders
Description: Working with an anthropologist and the basic anatomy of the facial muscles the sculptures are developed using each individual's unique skeletal traits to reveal the appearance of the person as they would have looked in life. These study models represent closed cases.
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| Title: Unc93b1 escorts three Toll-like receptors
Contact: Mary O'Reilly
Description: Unc93b1 is a multi-spanning transmembrane domain that is responsible for transporting Toll-like receptors 3, 7, and 9 from the endoplasmic reticulum to endosomes, where recognition of self-nucleic acids triggers signaling and autoantibody production.
Kono DH, et al. “Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus”. Proceedings of the National Academy of Sciences, USA 2009, 106, 12061-6.
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| Title: Superficial muscle groups, posterior view
Contact: Pam Little, CMI
Description: Superficial muscles of the upper and lower limbs and back.
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| Title: Back Exercise 1
Contact: Carlyn Iverson
Description: View of an exercise for the back, created digitally.
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| Title: Stretching Positions
Contact: Diana Marques
Description: These and several other images were done to illustrate the muscles involved in different stretching positions and how they affect the human body.
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| Title: Maxillofacial surgery skull
Contact: Alison Schroeer
Description: This medical illustration was created by medical illustrator Alison Schroeer of Schroeer Scientific Illustration, as part of a maxillofacial surgery series. It depicts branches of the external carotid artery branching into and near the temporalis muscle.
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| Title: Invitro Fertilization
Contact: Jane Whitney
Description: Illustration for a grade 9 science text book.
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| Title: Anterior view of human cruciate ligaments
Contact: William Hamilton
Description: Anterior view of human cruciate ligaments and related structures.
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| Title: Intestinal Vessels
Contact: Travis Vermilye
Description: Cadaver Sketch of Intestinal Vessels
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| Title: Female Reproductive Anatomy
Contact: Jane Whitney
Description: For a grade 6 human reproduction student text.
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| Title: Chromosomes
Contact: Science Picture Company
Description: A conceptual Image of chromosomes.
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| Title: Structural Proteins and the Cytoskeleton
Contact: Nicolle Rager Fuller
Description: A vast network of interconnected structural proteins permeate the cell, providing structure, order, and transport highways. A few of the cytoskeleton components shown include: actin, tubulin, cadherin, microtubules and transport vesicles carried by dynein.
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| Title: Cross section thorax and abdomen
Contact: Pam Little, CMI
Description: Diagrammatic anatomy of thorax and abdomen in cross section
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| Title: Human skeleton
Contact: Alison Schroeer
Description: This anatomical artwork of the anterior and posterior human skeleton has all bones labeled. This medical illustration was created by medical illustrator Alison Schroeer of Schroeer Scientific Illustration.
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| Title: Tony
Contact: Kathleen McKeehen
Description: Portrait
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| Title: Arm muscles, tendons; Leg skeleton, ligaments
Contact: Marjorie Leggitt
Description: Anatomical illustrations prepared for Denver Museum of Nature and Science - Expedition Health exhibit and educational materials
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| Title: Flu Viruses in the Throat
Contact: Dr Jon Heras
Description: Flu viruses in the throat. Computer artwork of influenza (flu) viruses (ovals) in a human throat. The lining of the throat includes cells that are covered in cilia (small hair-like projections). These cilia normally move rhythmically to help expel dust, micro-organisms and other particles. However, a large number of viruses in the throat can prevent the cilia from working properly, allowing the viruses to infect the cells of the throat and lungs.
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| Title: Male Reproductive Anatomy
Contact: Jane Whitney
Description: For a grade 6 human reproduction student text.
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| Title: DNA
Contact: Science Picture Company
Description: An illustration showing three DNA strands
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| Title: Mitochondria and Free Radicals
Contact: Nicolle Rager Fuller
Description: Created for Science News magazine, this illustration shows the free radicals that are formed in the electron transport chain of the mitochondrial ATP generation. These free radicals have been implicated in many diseases.
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| Title: Heart tissue layers
Contact: Carlyn Iverson
Description: The heart is composed of various tissue layers, each with a special function or structure. It is this combination of tissues, whether they be of muscle, connective tissue, or conduction fibers, that provides the heart it's durability and flexibility to pump for many years.
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| Title: Male Cross Section at L2-L3
Contact: Travis Vermilye
Description: Male cross sectional anatomy at the L2-L3 level. Digital Illustration.
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| Title: Human skull
Contact: Alison Schroeer
Description: This medical illustration shows an anterior view of a human skull. This anatomical artwork was created by medical illustrator Alison Schroeer of Schroeer Scientific Illustration to show the bones of the human head.
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| Title: Colonoscopy
Contact: Pam Little, CMI
Description: Patient education material depiciting colonoscope and colonoscopy procedure.
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| Title: Carbohydrate binding regulates inflammation
Contact: Mary O'Reilly
Description: By binding carbohydrates on adipocytes, the protein Mgl1 on monocytes regulates the recruitment of monocytic precursors of inflammatory macrophages to adipose tissue. This illustration was created for the January, 2010 Functional Glycomics Update (Nature Publishing Group) to accompany a highlight of the paper by Westcott DJ, et al. “MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity.” J Exp Med. 2009, 206, 3143-56.
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| Title: Pituitary Gland
Contact: Jane Whitney
Description: Simple illustration showing the pituitary gland's location and hormonal influence on the reproductive organs of the pre-adolescent teen.
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| Title: Brain and Skull Wireframe
Contact: Science Picture Company
Description: A side view of the skull and bones for the upper neck, wireframe appearance. The right hemisphere of the brain is also visible within the skull.
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| Title: Cancer Research and Surrogate Endpoints
Contact: Nicolle Rager Fuller
Description: Historically, drug trials judged the efficacy of a new drug by looking at it's ability to cure the given disease. Increasingly, surrogate endpoints are used as gauges for drug value. Examples are shown here for cancer research, including: tumor size, metastasis and cancer cell mobility and tumor antigens in the blood stream. Created for CR magazine,
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| Title: Submuscular Ulnar Nerve Transposition
Contact: Ikumi Kayama
Description: Plate for orthopedic surgery textbook for hand surgeons and residents.
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| Title: Human heart chambers
Contact: Alison Schroeer
Description: This medical illustration of the human heart was created by medical illustrator Alison Schroeer of Schroeer Scientific Illustration. Designed for patient education, it depicts the atriums, ventricles, and valves of the heart in cross-section.
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| Title: Alveoli
Contact: Travis Vermilye
Description: Alveoli of the lung
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| Title: Drug pump placement
Contact: Pam Little, CMI
Description: Placement of drug pump and intraspinal catheter for pain management
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| Title: Human Heart Study
Contact: Chris Sanders
Description: Gold point and carbon dust study.
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| Title: Homophilic binding regulates apoptosis
Contact: Mary O'Reilly
Description: PECAM is a glycoprotein that binds to glycans on other copies of PECAM on the same or other cells, regulating apoptosis. This illustration was created for the February, 2010 Functional Glycomics Update (Nature Publishing Group) to accompany a highlight of the paper by Kitazume S, et al. “{alpha}2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling.” J Biol Chem. 2010 285, 6515-21.
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| Title: Neural network
Contact: Dr Jon Heras
Description: Neural network. Computer artwork of several nerve cells (neurons) forming a neural network. Neurons are responsible for passing information around the central nervous system (CNS), and from the CNS to the rest of the body, as electrical impulses. A nerve cell comprises a central nerve cell body surrounded by numerous extensions. Most of these are dendrites, which collect information from other nerve cells or from sensory cells. Each neuron also has an extension called an axon, through which information passes outwards to other cells, including other nerve cells and muscle fibres. Dendrites and axons meet at junctions known as synapses (glowing).
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| Title: Microscopic Hair
Contact: Science Picture Company
Description: A microscopic close-up image of human hair and skin.
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| Title: Septoplasty Procedure: Left Hemitransfixion
Contact: Ikumi Kayama
Description: PowerPoint slide describing the technique used to correct a deviated septum to the right for ENT surgeons and residents.
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| Title: Vasectomy
Contact: Jane Whitney
Description: Anatomy of the male reproductive system and the location of a vasectomy, for a high school biology textbook.
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| Title: Infant Heart & Lungs
Contact: Travis Vermilye
Description: Image of heart and lungs of an infant
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| Title: Vagus nerve
Contact: Marjorie Leggitt
Description: Nine images created for a military self-defense book to illustrate human physiology, typical attack injuries, and how to avoid them. This image, developed in Adobe Illustrator, emphasizes the vagus nerve and its location in relationship to the spine.
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| Title: Aorta branches
Contact: Alison Schroeer
Description: Anatomical illustration of the branches of the aorta. Anterior view of portion of human circulatory system, created as medical illustration educational piece for pre-med or medical students.
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| Title: Small molecules for stem cell research
Contact: Mary O'Reilly
Description: This promotional poster was created for an R&D firm to highlight small molecule reagents for use in stem cell research.
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| Title: Human heart
Contact: Marjorie Leggitt
Description: Image created in Photoshop for Denver Museum of Nature and Science for educational panels.
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| Title: Anatomy of the Human Eye
Contact: Erica Beade
Description: This is a digital illustration of the anatomy of the human eye.
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| Title: Fertilization
Contact: Jane Whitney
Description: A simplified illustration of a sperm fertilizing an egg. For a grade 6 human reproduction student text.
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| Title: Skeleton Torso
Contact: Science Picture Company
Description: A side view of the bones of the upper body and skull.
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| Title: Nanosphere Chemotherapy and Cancer
Contact: Nicolle Rager Fuller
Description: Cancer biologists are harnessing nanotechology to help target chemotherapy directly to cancer cells and malignant tumors. Created for CR magazine.
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| Title: Neuroendoscopic Third Ventriculostomy
Contact: Ikumi Kayama
Description: Splash image illustration for Endoscopic Neurosurgery manual for neurosurgeons and residents.
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| Title: Serotonin Reuptake
Contact: Sara Krause
Description: This figure demonstrates the actions of the serotonin neurotransmitters (D) and the SSRI drug molecules (P). Serotonin passes from the vesicles (A) of the presynaptic neuron (G) where it is produced across the synaptic cleft and into the receptors (E) of the postsynaptic neuron (H). Once the serotonin binds to the receptors, a flow of ions is released creating a nerve impulse. Reuptake of serotonin occurs when some of the serotonin that is passed from the presynaptic neuron is recycled back into that neuron (see upward arrows and F). SSRIs (P) block this reuptake by blocking the channels (B) which allow for this reuptake of the serotonin (C). This increases the amount of serotonin in the synaptic cleft that can bind with receptors on the postsynaptic terminal. (Text adapted with permission from Dharmananda.)
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